The effect of 5,8,11,14-eicosatetraynoic acid on lipid metabolism.
Lipids, 1979/2;14(2):181-93.
PMID: 106197
Impact factor: 1.646
Abstract
The purpose of this presentation is to review the current state of knowledge regarding 5,8,11,14-eicosatetraynoic acid (ETYA, Ro 3-1428) and its effects on lipid metabolism. Accordingly, the topics discussed include hypocholesterolemic and dermatological studies involving ETYA in both animals and man, as well as the effects of ETYA on desaturase enzymes. Metabolic studies involving ETYA are also noted. Primary interest is focused on the effects of ETYA on selected processes of arachidonate metabolism, and the effect of ETYA on inflammation, platelet aggregation and tumor growth are discussed, keeping in mind the relevance of arachidonate metabolism to these processes.
MeSH terms
5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acids; Cholesterol; Dietary Fats; Epoprostenol; Fatty Acid Desaturases; Fatty Acids, Unsaturated; Humans; Indomethacin; Inflammation; Linoleic Acids; Lipid Metabolism; Lipoxygenase; Liver; Liver Neoplasms, Experimental; Male; Papilloma; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sebaceous Glands; Sebum; Seminal Vesicles; Thromboxane-A Synthase
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