Isolation and identification of morphine n-oxide alpha- and beta-dihydromorphines, beta- or gamma-isomorphine, and hydroxylated morphine as morphine metabolites in several mammalian species.
J Pharm Sci, 1979/2;68(2):133-40.
Yeh SY, Krebs HA, Gorodetzky CW
PMID: 106104
Impact factor: 3.784
Abstract
New morphine metabolites in the urine of guinea pigs, rats, rabbits, cats, monkeys, and humans were isolated with column chromatography, solvent extraction, and TLC and identified with TLC, GLC, and GLC-mass spectrometry. In addition to the known morphine metabolites, morphine N-oxide was isolated from the urine of guinea pigs, and alpha- and beta-dihydromorphines were isolated or detected in the urine of guinea pigs, rats, and rabbits. Monohydroxymorphine was identified tentatively in the urine of guinea pigs, rats, rabbits, and cats. Dihydroxymorphine was identified tentatively in the urine of guinea pigs, rats, and possibly, rabbits. Finally, beta- or gamma-isomorphine was identified tentatively in the urine of guinea pigs. The newly described morphine metabolites may be involved in some long lasting pharmacological effects of morphine.
MeSH terms
Animals; Biotransformation; Cats; Chromatography, Gas; Chromatography, Thin Layer; Dogs; Female; Glucuronates; Guinea Pigs; Haplorhini; Humans; Hydroxylation; Isomerism; Macaca mulatta; Male; Mass Spectrometry; Morphine; Morphine Dependence; Oxidation-Reduction; Rabbits; Rats; Time Factors
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