A rapidly polymerizing polyurethane for transcatheter embolization.
Cardiovasc Radiol, 1978/4/25;1(2):109-16.
Doppman JL, Aven W, Bowman RL, Wood LL, Girton M
PMID: 105808
Abstract
A polyurethane prepolymer was evaluated as a transcatheter embolizing agent. Low viscosity permits injection through small catheters. Polymerization is initated on contact with blood and completed within 10 seconds. Downstream propagation is better then that of cyanoacrylate and comparable to that of silicone rubber. No systemic toxicity was observed in acute animal experiments. However, dissolution of arterial walls and extravasation out of the vascular bed of chronically embolized organs suggest significant local tissue toxicity and make further evaluation necessary before clinical testing.
MeSH terms
Abscess; Animals; Catheterization; Cats; Dogs; Embolization, Therapeutic; Haplorhini; Hepatic Artery; Kidney Diseases; Polymers; Polyurethanes; Radiography; Renal Artery; Sheep
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