Effects of protein depletion and repletion on cell-mediated immunity in experimental animals.
Ann Surg, 1978/12;188(6):791-6.
Daly JM, Dudrick SJ, Copeland EM
PMID: 104668
Impact factor: 13.787
Abstract
Protein-calorie malnutrition leads to depression of host cell-mediated immunity. Nutritional repletion initially results in rapid weight gain followed by a more gradual return of immunocompetence. Administration of a synthetic amino acid diet to normal animals did not preserve body weight or cell-mediated immunity any better than did a high carbohydrate, protein-free diet. Administration of a synthetic amino acid diet to malnourished animals maintained body weight, but did not restore immunocompetence. Proper nutritional repletion should provide both adequate protein and nonprotein calories if a return of immunocompetence is to be anticipated.
MeSH terms
Amino Acids; Animals; Antibody Formation; Body Weight; Dietary Carbohydrates; Dietary Proteins; Immunity, Cellular; Protein-Energy Malnutrition; Rats; Tuberculin Test
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