Enzyme-immunoassay in diagnosis of hepatitis with emphasis on the detection of "e" antigen (HBeAg).
J Med Virol, 1978;3(1):43-9.
von der Waart M, Snelting A, Cichy J, Wolters G, Schuurs A
PMID: 104001
Impact factor: 20.693
Abstract
A brief survey of the application of enzyme-immunoassay (EIA) for the detection of hepatitis B surface antigen (HBsAg), hepatitis A, and their corresponding antibodies is given. The preliminary results of a similar EIA for detection of hepatitis B-related "e" antigen (HBeAg) and its antibody (anti-HBe) are reported. This EIA is much more sensitive than immunodiffusion: at least 128 times for HBeAg and at least 512 times for anti-HBe. HBsAg and its antibody do not interfere with the test. Only a few sera strongly positive for rheumatoid factor gave rise to false-positive results, as was demonstrated by a confirmatory test.
MeSH terms
Carrier State; Diagnosis, Differential; Enzyme-Linked Immunosorbent Assay; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Antigens; Humans; Immunodiffusion; Immunoenzyme Techniques
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