Reduction of respiratory tract binding of benzo[a]pyrene in mice by immunization.
J Natl Cancer Inst, 1978/11;61(5):1347-9.
Moolten F, Capparell N, Boger E
PMID: 101677
Impact factor: 11.816
Abstract
Male inbred A/J mice immunized by combined ip and intranasal administration of a bovine serum albumin conjugate of 5-fluoro-12-methylbenzanthryl-7-acetic acid developed tracheal antibodies capable of binding the carcinogen benzo[a]pyrene (BP). Immunized mice administered 92 ng of [3H]BP intranasally exhibited a one-third reduction in BP content in respiratory tract tissues (nose and trachea) when compared with control mice 20 hours after BP administration.
MeSH terms
9,10-Dimethyl-1,2-benzanthracene; Animals; Antibody Formation; Antigens; Benz(a)Anthracenes; Benzopyrenes; Male; Mice; Mice, Inbred A; Nasal Mucosa; Nose; Respiratory Tract Neoplasms; Serum Albumin, Bovine; Trachea
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