Effects of iron and culture filtrates on killing of Neisseria gonorrhoeae by normal human serum.
Infect Immun, 1978/9;21(3):918-24.
PMID: 101468
Impact factor: 3.609
Abstract
Neisseria gonorrhoeae GC9, both colony types T2 and T4, were killed by normal human serum, although populations of colony type T4 were more susceptible. Ferric ammonium citrate prevented the killing of populations of both T2 and T4 colony types. Other iron compounds tested showed no protective effect, nor did ammonium citrate or the divalent cations magnesium or calcium. A filtrate from cultures of an N. gonorrhoeae strain grown in a liquid defined medium showed a similar protective effect in the serum assay. The filtrate appeared to chelate iron, as measured by decreased ability of iron-free transferin to bind iron in the presence of the filtrate. However, the two effects did not appear to be related. Neither ferric ammonium citrate nor the culture filtrate sufficiently inactivated complement to account for protection.
MeSH terms
Blood Bactericidal Activity; Cations; Complement System Proteins; Culture Media; Depression, Chemical; Humans; Iron; Kinetics; Neisseria gonorrhoeae
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