Somatostatin inhibits release of thyrotropin releasing factor from organ cultures of rat hypothalamus.
Proc Natl Acad Sci U S A, 1978/9;75(9):4509-13.
Hirooka Y, Hollander CS, Suzuki S, Ferdinand P, Juan SI
PMID: 100786
Impact factor: 12.779
Abstract
Somatostatin in concentrations of 10(-6) to 10(-8) M inhibited basal release of thyrotropin releasing factor in organ culture of rat hypothalamus. Norepinephrine in doses of 10(-4)--10(-6) M induced release of thyrotropin releasing factor which increased progressively with time and was temperature and dose dependent. This enhanced thyrotropin-releasing-factor release was inhibited by somatostatin at 10(-6)--10(-8) M.
MeSH terms
Animals; Hypothalamus; Kinetics; Norepinephrine; Organ Culture Techniques; Radioimmunoassay; Rats; Somatostatin; Temperature; Thyrotropin-Releasing Hormone
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