Hodgkin's disease: radiotherapeutic management at a cancer oriented community hospital.
Cancer, 1978/9;42(3):1046-56.
PMID: 100196
Impact factor: 6.921
Abstract
Seventy-eight patients with Hodgkin's disease were treated with radiation therapy between July 1966 and July 1976 (30 Stage I, 28 Stage II, 20 Stage III). The mean follow-up period is greater than 5 years. 90% of Stage I, 86% of Stage II, 65% of Stage III, and 82% (64/78) of all patients are NED after radiotherapy alone. Since laparotomy option (1970) 89% (50/56) of patients are NED. Fourteen patients were failures. Chemotherapy "rescued" 6 of 14. Seven have died, 1 is alive with disease, and 1 died of leukemia. Absolute survival is 90% (70/78). Failures were more frequent in patients with unfavorable histological types (9/14), and Stage III disease, primarily IIIS+ or B category (7/14). Sites of failures were mainly extranodal, primarily lung (10/14) and bone (2/14), and are consistent with hematogenous dissemination. Laparotomy performed in 41 patients identified unsuspected splenic involvement in 9 cases (22%), but was a distinct failure in confirming most "small node" positive lymphangiograms. Two patients developed acute myelocytic leukemia, both while NED 5 years posttherapy. One patient had also received adjunctive MOPP. There has been no impairment in the quality of survival that could be directly attributed to radiotherapy.
MeSH terms
Adolescent; Adult; Aged; Female; Herpes Zoster; Hodgkin Disease; Hospitals, Community; Humans; Laparotomy; Leukemia, Myeloid, Acute; Male; Middle Aged; Neoplasm Staging; Neoplasms, Multiple Primary; New York; Pancreas; Radiation Injuries; Radiotherapy, High-Energy; Recurrence; Remission, Spontaneous; Splenectomy
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