Full name: bromodomain and WD repeat domain containing 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: C21orf107; DCAF19; N143; WDR9; WRD9

Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011]

Expression: Ubiquitous expression in testis (RPKM 5.8), brain (RPKM 4.9) and 25 other tissues

Gene size: 137037bp

Exon count: 46