Full name: endoplasmic reticulum aminopeptidase 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP; ERAAP1; PILS-AP; PILSAP

Summary: The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

Expression: Ubiquitous expression in fat (RPKM 18.4), duodenum (RPKM 14.7) and 25 other tissues

Gene size: 175042bp

Exon count: 27