Full name: synaptotagmin I

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: G630098F17Rik; SytI

Summary: Enables several functions, including calcium ion sensor activity; calcium-dependent phospholipid binding activity; and syntaxin-1 binding activity. Involved in modulation of chemical synaptic transmission; regulation of dopamine secretion; and synaptic vesicle exocytosis. Acts upstream of or within calcium ion-regulated exocytosis of neurotransmitter; spontaneous neurotransmitter secretion; and synchronous neurotransmitter secretion. Located in several cellular components, including glutamatergic synapse; presynaptic membrane; and secretory vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and sensory organ. Orthologous to human SYT1 (synaptotagmin 1). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in cortex adult (RPKM 49.2), frontal lobe adult (RPKM 47.7) and 4 other tissues

Gene size: 513342bp

Exon count: 16