Full name: cAMP responsive element modulator

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CREM-2; ICER; hCREM-2

Summary: This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]

Expression: Broad expression in testis (RPKM 19.2), adrenal (RPKM 15.7) and 21 other tissues

Gene size: 86113bp

Exon count: 19