China is the most populous country and the second largest economy in the world.
However, the construction of Chinese genome database is in slow progress. At present, among the
world's large-scale international and national genome sequencing projects, such as 1KGP,
Genomics England, Genome of the Netherlands, ExAC are mostly biased towards the construction of
a genomic baseline for European populations. In those projects, while the sample size goes up to
hundreds of thousands for samples with european ancestry in those database, the sequencing Chinese
samples is no more than a thousand.
Since a high-quality genomic baseline database serves as an important control for medical research
and population-oriented clinical and drug applications, the Chinese millionome database (CMDB) is
developed to fill the gap.
The Chinese Millionome Database(CMDB) is a unique large-scale Chinese genomics
database produced by BGI and hosted in the National GeneBank. The CMDB delivers peridical and
useful variation information and scientific insights derived from the analysis of millions of
Chinese sequencing data. The results aim to promote genetic research and precision medicine actions
The delivering information includes any of detected variants and the corresponding allele frequency,
annotation, frequency comparison to the global populations from existing databases, etc.
Samples with informed consent are chosen for analysis. Projects are carried out with
ethical approval and follow China's regulation on administration of Human Genetic Resources.
The Phase I results including comprehensive variation and their allele frequency information
from 141,431 unrelated healthy Chinese individuals.The article was published in the scientific journal Cell.
DOI: 10.1016/j.cell.2018.08.016 or
You can search variant, gene or genomic regions that you expect to obtain the variation
information, including mutation, allele frequency, annotation, frequency comparison to the
global populations from existing databases.