Over the past decade, comprehensive sequencing efforts have revealed the genomic landscapes of common forms of human cancer. To date, these studies have revealed ~140 genes that, when altered by intragenic mutations, can promote or "drive" tumorigenesis. A typical tumor contains two to eight of these "driver gene" mutations; the remaining mutations are passengers that confer no selective growth advantage. Driver genes can be classified into 12 signaling pathways that regulate three core cellular processes: cell fate, cell survival, and genome maintenance. A better understanding of these pathways is one of the most pressing needs in basic cancer research. Even now, however, our knowledge of cancer genomes is sufficient to guide the development of more effective approaches for reducing cancer morbidity and mortality.
Estimates for the 21 world regions and for more and less developed regions are calculated as the population-weighted average of the incidence and mortality rates of the component countries. The data is from (2015), Global cancer statistics, 2012.
Based on GLOBOCAN estimates, about 14.1 million new cancer cases and 8.2 million deaths occurred in 2012 worldwide. Over the years, the burden has shifted to less developed countries, which currently account for about 57% of cases and 65% of cancer deaths worldwide. Although incidence rates for all cancers combined are nearly twice as high in more developed than in less developed countries in both males and females, mortality rates are only 8% to 15% higher in more developed countries. This disparity reflects regional differences in the mix of cancers, which is affected by risk factors and detection practices, and/or the availability of treatment. Risk factors associated with the leading causes of cancer death include tobacco use (lung, colorectal, stomach, and liver cancer), overweight/obesity and physical inactivity (breast and colorectal cancer), and infection (liver, stomach, and cervical cancer). A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.
Reference: (2015), Global cancer statistics, 2012
The Cancer Database includes donor information such as age, sex, race, year of diagnosis, and geographic areas, sequencing data, and processed data such as mutation, variation. Use of these data for publication purposes should contain a citation which includes submission and release dates.
|Data amount||20.1 TB|
In each panel below, the right side is the top 10 tumour type from (2015), Global cancer statistics, 2012, and the left side is the data amount (GB) and donor statistics sorted by age in this database.
Legends: Data Amount(0-19), Data Amount(20-39), Data Amount(40-59), Data Amount(60-79), Data Amount(80+), Donor(0-19), Donor(20-39), Donor(40-59), Donor(60-79), Donor(80+).