VThunter
a database for single-cell screening of virus target cells in animal kingdom
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Mongolian horse

Scientific Name: Equus caballus

Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Laurasiatheria-> Perissodactyla-> Equidae-> Equus-> Equus

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Simian immunodeficiency virus

Family: Reoviridae

Receptor: CCR5

Receptor CCR5 information

Summary: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015] [NCBI]  [Proteinatlas]

Data Source

Data set information

Project Date Technology Tissue Condition Cell PMID/DOI
Vthunter_0066 2021.04 iDrop PBMC Normal 12794 Link
Featureplot of receptors

Featureplot of receptors

mRNA expression of CCR5 in human tissues   [NCBI]

Expression: Broad expression in appendix (RPKM 9.4), lymph node (RPKM 7.4) and 21 other tissues

Protein expression of CCR5 in human tissues   [Proteinatlas]