Scientific Name: Panthera tigris altaica
Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Laurasiatheria-> Carnivora-> Feliformia-> Felidae-> Pantherinae-> Panthera-> Panthera tigris
Summary: This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Nov 2020] [NCBI] [Proteinatlas]
Data set information
| Project | Date | Technology | Tissue | Condition | Cell | PMID/DOI |
|---|---|---|---|---|---|---|
| Vthunter_0023 | 2021.04 | 10X Genomics | Heart | Normal | 16479 | Link |
| Vthunter_0024 | 2021.04 | 10X Genomics | Kidney | Normal | 3483 | Link |
| Vthunter_0025 | 2021.04 | 10X Genomics | Liver | Normal | 10237 | Link |
| Vthunter_0026 | 2021.04 | 10X Genomics | Lung | Normal | 14159 | Link |
| Vthunter_0027 | 2021.04 | 10X Genomics | Spleen | Normal | 33029 | Link |
| Vthunter_0057 | 2021.04 | iDrop | PBMC | Normal | 4755 | Link |
Featureplot of receptors
Expression: Broad expression in placenta (RPKM 53.3), fat (RPKM 49.6) and 24 other tissues
