VThunter

Drosophila

Scientific Name: Drosophila melanogaster

Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Protostomia-> Ecdysozoa-> Panarthropoda-> Arthropoda-> Mandibulata-> Pancrustacea-> Hexapoda-> Insecta-> Dicondylia-> Pterygota-> Neoptera-> Endopterygota-> Diptera-> Brachycera-> Muscomorpha-> Eremoneura-> Cyclorrhapha-> Schizophora-> Acalyptratae-> Ephydroidea-> Drosophilidae-> Drosophilinae-> Drosophilini-> Drosophila-> Sophophora-> melanogaster group-> melanogaster subgroup

Middle East respiratory syndrome-related coronavirus

Family: Coronaviridae

Receptor: DPP4

Receptor DPP4 information

Summary: The DPP4 gene encodes dipeptidyl peptidase 4, which is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic type II transmembrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Dipeptidyl peptidase 4 is highly involved in glucose and insulin metabolism, as well as in immune regulation. This protein was shown to be a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV), and protein modeling suggests that it may play a similar role with SARS-CoV-2, the virus responsible for COVID-19. [provided by RefSeq, Apr 2020] [NCBI] [Proteinatlas]

Data Source

Data set information

Project	Date	Technology	Tissue	Condition	Cell	PMID/DOI
Vthunter_1007	2017.12	Smart-seq2	Brain	Normal	1842	Link
Vthunter_1012	2018.09	Drop-seq	EyeDisc	Normal	6200	Link

mRNA expression of DPP4 in human tissues [NCBI]

Expression: Biased expression in small intestine (RPKM 70.7), placenta (RPKM 57.1) and 13 other tissues