VThunter
a database for single-cell screening of virus target cells in animal kingdom
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Rat

Scientific Name: Rattus norvegicus

Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Euarchontoglires-> Glires-> Rodentia-> Myomorpha-> Muroidea-> Muridae-> Murinae

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Jaagsiekte sheep retrovirus

Family: Reoviridae

Receptor: HYAL2

Receptor HYAL2 information

Summary: This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.[provided by RefSeq, Mar 2010] [NCBI]  [Proteinatlas]

Data Source

Data set information

Project Date Technology Tissue Condition Cell PMID/DOI
Vthunter_1001 2019.12 10X Genomics Lung Normal 5029 Link
Vthunter_1002 2019.12 10X Genomics Lung Normal 5924 Link
Vthunter_1009 2017.11 Fluidigm C1 UrogenitalSinus Normal 114 Link
Vthunter_110073 2019.12 MARS-seq TotalBrain Normal 2304 Link
Featureplot of receptors

Featureplot of receptors

mRNA expression of HYAL2 in human tissues   [NCBI]

Expression: Broad expression in spleen (RPKM 78.9), lung (RPKM 35.1) and 20 other tissues

Protein expression of HYAL2 in human tissues   [Proteinatlas]