Scientific Name: Sus scrofa domestica
Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Laurasiatheria-> Artiodactyla-> Suina-> Suidae-> Sus-> Sus scrofa
Summary: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015] [NCBI] [Proteinatlas]
Data set information
Project | Date | Technology | Tissue | Condition | Cell | PMID/DOI |
---|---|---|---|---|---|---|
Vthunter_0046 | 2021.04 | 10X Genomics | Lung | Normal | 21981 | Link |
Vthunter_0069 | 2021.04 | 10X Genomics | Frontal | Normal | 8812 | Link |
Vthunter_0070 | 2021.04 | 10X Genomics | Occipital | Normal | 6829 | Link |
Vthunter_0071 | 2021.04 | 10X Genomics | Parietal | Normal | 6162 | Link |
Vthunter_0072 | 2021.04 | 10X Genomics | Hypothalamus | Normal | 7302 | Link |
Vthunter_0073 | 2021.04 | 10X Genomics | Temporal | Normal | 3145 | Link |
Vthunter_0074 | 2021.04 | iDrop | Lung | Normal | 13580 | Link |
Vthunter_0074 | 2021.04 | iDrop | Lung | Normal | 13580 | Link |
Vthunter_0074 | 2021.04 | iDrop | Lung | Normal | 13580 | Link |
Vthunter_0074 | 2021.04 | iDrop | Lung | Normal | 13580 | Link |
Vthunter_0074 | 2021.04 | iDrop | Lung | Normal | 13580 | Link |
Vthunter_0074 | 2021.04 | iDrop | Lung | Normal | 13580 | Link |
Vthunter_1013 | 2019.12 | 10X Genomics | Lung | Normal | 7465 | Link |
Vthunter_1014 | 2019.12 | 10X Genomics | Lung | Normal | 3987 | Link |
Featureplot of receptors
Expression: Broad expression in appendix (RPKM 9.4), lymph node (RPKM 7.4) and 21 other tissues