VThunter
a database for single-cell screening of virus target cells in animal kingdom
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Tiger

Scientific Name: Panthera tigris altaica

Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Laurasiatheria-> Carnivora-> Feliformia-> Felidae-> Pantherinae-> Panthera-> Panthera tigris

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Hepacivirus C

Family: Flaviviridae

Receptor: LDLR

Receptor LDLR information

Summary: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010] [NCBI]  [Proteinatlas]

Data Source

Data set information

Project Date Technology Tissue Condition Cell PMID/DOI
Vthunter_0023 2021.04 10X Genomics Heart Normal 16479 Link
Vthunter_0024 2021.04 10X Genomics Kidney Normal 3483 Link
Vthunter_0025 2021.04 10X Genomics Liver Normal 10237 Link
Vthunter_0026 2021.04 10X Genomics Lung Normal 14159 Link
Vthunter_0027 2021.04 10X Genomics Spleen Normal 33029 Link
Featureplot of receptors

Featureplot of receptors

mRNA expression of LDLR in human tissues   [NCBI]

Expression: Ubiquitous expression in adrenal (RPKM 29.0), lung (RPKM 28.5) and 25 other tissues?

Protein expression of LDLR in human tissues   [Proteinatlas]