Scientific Name: Felis catus
Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Laurasiatheria-> Carnivora-> Feliformia-> Felidae
Summary: The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] [NCBI] [Proteinatlas]
Data set information
| Project | Date | Technology | Tissue | Condition | Cell | PMID/DOI |
|---|---|---|---|---|---|---|
| Vthunter_0028 | 2021.04 | 10X Genomics | Esophagus | Normal | 1928 | Link |
| Vthunter_0029 | 2021.04 | 10X Genomics | Eyelid | Normal | 679 | Link |
| Vthunter_0030 | 2021.04 | 10X Genomics | Heart | Normal | 8209 | Link |
| Vthunter_0031 | 2021.04 | 10X Genomics | Kidney | Normal | 2831 | Link |
| Vthunter_0032 | 2021.04 | 10X Genomics | Liver | Normal | 7889 | Link |
| Vthunter_0033 | 2021.04 | 10X Genomics | Lung | Normal | 8591 | Link |
| Vthunter_0034 | 2021.04 | 10X Genomics | Rectum | Normal | 1503 | Link |
Featureplot of receptors
Expression: Broad expression in spleen (RPKM 22.7), appendix (RPKM 22.2) and 17 other tissues?
